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Abstract #4025

Hyperpolarized 13C lactate as a substrate for in vivo metabolic studies in skeletal muscle

Jessica A.M. Bastiaansen 1 , Hikari A.I. Yoshihara 2,3 , Yuhei Takado 2,4 , Rolf Gruetter 1,5 , and Arnaud Comment 2

1 Laboratory of Functional and Metabolic Imaging, EPFL, Lausanne, Switzerland, 2 Institute of Physics of Biological Systems, EPFL, Lausanne, Switzerland, 3 Department of Cardiology, CHUV, Lausanne, Switzerland, 4 Laboratory of Biological Geochemistry, EPFL, Lausanne, Switzerland, 5 Department of Radiology, University of Geneva and University of Lausanne, Lausanne, Switzerland

Lactate is not merely an end product in skeletal muscle metabolism but also an important metabolic intermediate. Using hyperpolarized 13C MRS, lactate metabolism can be investigated in real time, injected at physiological concentrations leaving other oxidative processes undisturbed. Here we investigated the use of hyperpolarized 13C lactate as a substrate for metabolic studies in skeletal muscle in vivo, in different nutritional states. The herein proposed method allows probing simultaneously both PDH activity and variations in alanine tissue concentration, which are associated with metabolic dysfunctions.

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