Mapping the Creatine Kinase Reaction Rate in Muscles of the Lower Leg Using Progressive Saturation 31P-MRI at 3.0 T.
Prodromos Parasoglou 1 , Ding Xia 1 , Greg Chang 1 , and Ravinder R Regatte 1
Radiology, NYU School of Medicine, New York,
New York, United States
The creatine kinase reaction plays an important role is
skeletal muscle. In this work we developed and
implemented a progressive saturation three-dimensional
31P-MRI method for mapping the kinetics of the creatine
kinase reaction, and the unidirectional phosphocreatine
to adenosine triphosphate metabolic fluxes in muscles of
the lower leg at 3.0 T. Mapping the kinetics of the
creatine kinase reaction with large tissue coverage and
relatively high spatial resolution is a promising method
for the diagnosis and monitoring of several diseases
that affect function of skeletal muscle.
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