Mapping the Creatine Kinase Reaction Rate in Muscles of the Lower Leg Using Progressive Saturation 31P-MRI at 3.0 T.

The creatine kinase reaction plays an important role is skeletal muscle. In this work we developed and implemented a progressive saturation three-dimensional 31P-MRI method for mapping the kinetics of the creatine kinase reaction, and the unidirectional phosphocreatine to adenosine triphosphate metabolic fluxes in muscles of the lower leg at 3.0 T. Mapping the kinetics of the creatine kinase reaction with large tissue coverage and relatively high spatial resolution is a promising method for the diagnosis and monitoring of several diseases that affect function of skeletal muscle.

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