Abstract #4029
35Cl and 23Na MRI of 9L rat glioma at 21.1 T
Victor D. Schepkin 1 , Malathy Elumalai 2 , Jason Kitchen 3 , Chunqi Qian 4 , Peter Gor'kov 1 , and William Brey 1
1
CIMAR, NHMFL/FSU, Tallahassee, FL, United
States,
2
AMRIS,
NHMFL/UF, Gainesville, FL, United States,
3
CIMAR,
NHMFL/FSU, Tallahassee, Florida, United States,
4
NINDS/NIH,
Bethesda, MD, United States
Chloride is a unique window for investigating brain
function and cancer development. The in vivo challenges
of low sensitivity, short T2 relaxation time and the
small size of the acquisition matrix were evaluated
here. The experiments in normal rat brain and glioma
revealed: chloride in vivo is as visible as the sodium
MR signal. However, the bi-exponential FID and limited
sampling size dramatically affect the quantification of
images and needs to be corrected according to the
developed Matlab model. The finding of increased
chloride concentration in glioma correlates with the
hypothesis stating a critical role of chloride for tumor
progression.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
