Abstract #4030
Mn-enhanced MRI for early tumor detection and in vivo growth rate analysis in a mouse medulloblastoma model
Giselle A. Suero-Abreu 1,2 , G. Praveen Raju 3 , Orlando Aristizabal 1 , Eugenia Volkova 1 , Edward J. Houston 1 , Diane Pham 3 , Alexandre Wojcinski 4 , Kamila U. Szulc 1 , Daniel Colon 1 , Alexandra L. Joyner 4 , and Daniel H. Turnbull 1,2
1
Skirball Institute of Biomolecular Medicine,
NYU School of Medicine, NY, NY, United States,
2
Department
of Radiology, NYU School of Medicine, NY, NY, United
States,
3
Department
of Pediatrics, Weill Cornell Medical College, NY, NY,
United States,
4
Developmental
Biology Program, Sloan-Kettering Institute, Memorial
Sloan-Kettering Cancer Center, NY, NY, United States
Mouse models of medulloblastoma have led to important
new insights into the etiology of this common malignant
pediatric brain tumor. In the current study, Mn-enhanced
MRI (MEMRI) was used to characterize tumor progression
in mice with a conditional knockout of Ptch1, a mouse
model of sporadic medulloblastoma. 3D MEMRI enabled
early detection of pre-neoplastic lesions (validated by
histology), and longitudinal MEMRI was used to quantify
tumor progression in individual mice. Measured tumor
growth rates were heterogeneous, leading to the
interesting future potential of MEMRI for guiding
histological and micro-array analyses of molecular
differences between fast and slow progressing
medulloblastomas.
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