Abstract #4037
Studying glioblastoma progression in a rat model of human glioma initiating cells using 1H MRS and DTI
Mor Mishkovsky 1,2 , Cristina Cudalbu 3 , Emine Can 4 , Denis Mario 5 , Ivan Radovanovic 5 , Arnaud Comment 4 , Virginie Clment-Schatlo 5 , and Rolf Gruetter 1,6
1
Laboratory for Functional and Metabolic
Imaging (LIFMET), Ecole Polytechnique Fdrale de
Lausanne (EPFL), Lausanne, Switzerland,
2
Department
of radiology, Univesity of Lausanne, Lausanne,
Switzerland,
3
CIBM,
Ecole Polytechnique Fdrale de Lausanne (EPFL),
Lausanne, Switzerland,
4
Institute
of Physics of Biological Systems, Ecole Polytechnique
Fdrale de Lausanne (EPFL), Lausanne, Switzerland,
5
Hpitaux
Universitaires de Genve (HUG), Geneva, Switzerland,
6
Department
of radiology, Univesity of Lausanne and Geneva,
Switzerland
Glioblastoma tumorigenesis and its effect on cerebral
metabolism were studied longitudinally in a rat model of
human glioma initiation cells (GIC). In vivo 1H MRS
spectra were measured to characterize brain metabolism
and diffusion tensor imaging (DTI) acquisitions allowed
to visualize morphological changes between healthy and
malignant tissue. Both DTI and 1H MRS indicated the
onset of the tumor at similar time point, yet at this
early stage the differences between the tumors and the
contralateral hemisphere were more evident in the
spectroscopic data.
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