Abstract #4038
Heterogeneity of Tumor Vasculature and Antiangiogenic Intervention by MR Angiography and DCE-MRI Investigation
Wenlian Zhu 1 , Yoshinori Kato 1,2 , and Dmitri Artemov 1,2
1
Division of Cancer Imaging Research, The
Russell H. Morgan Department of Radiology and
Radiological, The Johns Hopkins University School of
Medicine, BALTIMORE, Maryland, United States,
2
Department
of Oncology, The Sidney Kimmel Comprehensive Cancer
Center, The Johns Hopkins University School of Medicine,
Maryland, United States
Vasculature of solid tumors is intrinsically
heterogeneous, which presents challenges to
antiangiogenic intervention as well as the evaluation of
its therapeutic efficacy. Here we evaluated the tumor
vascular changes in response to bevacizumab/paclitaxel
therapy using a combination approach of MR angiography
and DCE-MRI method. Results showed that macroscopic
feeding vessels were not affected by the bevacizumab/paclitaxel
treatment. A higher portion of the tumors was within
close proximity of these large vessels after the
treatment, concomitant with tumor growth retardation. A
significant decrease in microvascular permeability and
vascular volume in regions near these macroscopic
vessels was observed.
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