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Abstract #4038

Heterogeneity of Tumor Vasculature and Antiangiogenic Intervention by MR Angiography and DCE-MRI Investigation

Wenlian Zhu 1 , Yoshinori Kato 1,2 , and Dmitri Artemov 1,2

1 Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological, The Johns Hopkins University School of Medicine, BALTIMORE, Maryland, United States, 2 Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Maryland, United States

Vasculature of solid tumors is intrinsically heterogeneous, which presents challenges to antiangiogenic intervention as well as the evaluation of its therapeutic efficacy. Here we evaluated the tumor vascular changes in response to bevacizumab/paclitaxel therapy using a combination approach of MR angiography and DCE-MRI method. Results showed that macroscopic feeding vessels were not affected by the bevacizumab/paclitaxel treatment. A higher portion of the tumors was within close proximity of these large vessels after the treatment, concomitant with tumor growth retardation. A significant decrease in microvascular permeability and vascular volume in regions near these macroscopic vessels was observed.

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