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Abstract #4039

Does the presence of micro-vasculature alter the dispersion properties of shear waves? A rat aortic ring model at multiple frequencies using Magnetic Resonance Elastography.

Lauriane Juge 1,2 , Anne Petiet 3 , Simon A. Lambert 2 , Pascal Nicole 2 , Simon Chatelin 2,4 , Sabrina Doblas 2 , Valerie Vilgrain 2,5 , Bernard E. Van Beers 2,5 , and Ralph Sinkus 2,6

1 Neuroscience Research Australia, Randwick, Sydney, NSW, Australia, 2 CRB3-INSERM U773, University Paris Diderot, Paris, France, 3 IFR02-CEFI, University Paris Diderot, Paris, France, 4 Laboratoire Ondes et Acoustique / Institut Langevin, ESPCI, Paris, France, 5 Radiology, Beaujon Hospital, Clichy, Paris, France, 6 Division of Imaging Sciences and Biomedical Engineering, Kings College London, Kings Health Partners, St. Thomas Hospital, London, United Kingdom

Disease or therapies can change the mechanical integrity and organization of vascular structures. If blood vessels represent a source for wave scattering, Magnetic Resonance Elastography (MRE) should be able to sense these changes. Considering the hypothesis that the presence of an underlying fractal-like stiff structure is capable of generating on the macroscopic scale power law behavior, multi-frequency MRE (100-150Hz) was performed to quantify alteration of the shear wave speed due to the presence of vascular outgrowth using a rat aortic ring model. Results support the ability of using shear wave diffusion parameters to probe the structure of the vascular bed.

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