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Abstract #4045

Effects of Trabectedine on tumour growth and metabolism in preclinical models of HER-2 overexpressing ovarian cancer

Egidio Iorio 1 , Fabio Ginnari Satriani 1 , Alessandro Ricci 1 , Emiliano Surrentino 1 , Marina Bagnoli 2 , Paola Alberti 2 , Franca Podo 1 , Delia Mezzanzanica 2 , and Rossella Canese 1

1 Cell Biology and Neurosciences Dept, Istituto Superiore di Sanit, Rome, Italy, 2 Experimental Oncology Dept, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Epithelial ovarian cancer (EOC) is a heterogeneous disease with a poor prognosis. Evaluation of metabolic effects of anticancer therapies would enhance the capability of non invasive imaging approaches to monitor molecular mechanisms underlying tumour responsiveness. Here we explore the role of MRI/MRS in the detection of the cytotoxic response of trabectedin (ET-743, a new marine-derived antitumor agent, which has shown in vitro and in vivo activity in ovarian cancer) in experimental EOC models, showing previously unexplored trabectedine-induced metabolic and morphofunctional changes.

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