Abstract #4046
Poly(I:C) Treatment in a Spontaneous Hepatocellular Carcinoma Mouse Model
Jeffrey David Steinberg 1 , Justin Lee 2 , Philipp Kaldis 3 , Jean-Pierre Abastado 2,4 , and Valerie Chew 2
1
Singapore Bioimaging Consortium, Agency for
Science, Technology and Research, Singapore, Singapore,
2
Singapore
Immunology Network, Agency for Science, Technology and
Research, Singapore, Singapore,
3
Institute
of Molecular and Cell Biology, Agency for Science,
Technology and Research, Singapore, Singapore,
4
Institut
de Recherches Internationales Servier, Suresnes, France
Hepatocellular carcinoma (HCC) is the 6th most common
cancer with the 3rd highest mortality worldwide.
Prognosis for HCC is generally poor with a 5-year
survival rate of only 15%. In this study a spontaneous
HCC mouse model was treated using poly(I:C), a synthetic
TLR3 ligand that activates NK cells and is cytotoxic to
HCC cells. Using a 3D T1-weighted MPRAGE MRI sequence,
the tumor progression could be monitored. Average tumor
growth was 8 times and 183 times the pre-therapy tumor
volume for the treatment and control mice respectively.
Thus, poly(I:C) was effective in delaying HCC tumor
growth.
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