Extracellular sodium MRI, a non-invasive endogenous marker for tumoral response to photodynamic therapy associated with nitroglycerin.

The aim of this study was double. Firstly, to determine if photodynamic therapy associated with nitroglycerin ointment was able to induce a major cellular death on a tumoral line of retinoblastoma that was less responsive to treatment. Secondly to determine if extracellular MRI follow-up is able to give rapid information about tumor cells destruction. Nitroglycerin increased the photosensitzer concentration at the tumor level and hence the treatment efficiency. Sodium MRI monitored non-invasively the cellular destruction, showing a local increase of sodium concentration specific to extracellular sodium amount all over where cells were irreversible damaged by PDT.

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