Abstract #4070
Collagen fibers mediate water diffusion and anisotropy in breast tumors
Samata Kakkad 1,2 , Jiangyang Zhang 1 , Alireza Akhbardeh 1 , Desmond Jacob 1 , Meiyappan Solaiyappan 1 , Michael A. Jacobs 1,3 , Venu Raman 1,3 , Dieter Leibfritz 2 , Kristine Glunde 1,3 , and Zaver M. Bhujwalla 1,3
1
The Russell H. Morgan Department of
Radiology and Radiological Science, The Johns Hopkins
University School of Medicine, Baltimore, Maryland,
United States,
2
Department
of Chemistry and Biology, University of Bremen, Bremen,
Germany,
3
Sidney
Kimmel Comprehensive Cancer Center, The Johns Hopkins
University School of Medicine, Baltimore, Maryland,
United States
We investigated the influence of collagen 1 (Col1)
fibers on water diffusion, using a breast cancer
xenograft fluorescing under hypoxia. High Col1 fiber
density correlated with increased apparent diffusion
coefficient (ADC) and fractional anisotropy (FA).
Hypoxic regions contained significantly fewer Col1
fibers, and were characterized by lower ADC and FA
compared to normoxic tumor regions. Diffusion patterns
observed in vivo were spatially similar to those
observed ex vivo, suggesting that noninvasive DTI can be
used to evaluate Col1 fiber density, an important
biomarker of tumor progression, and highlighting the
importance of Col1 fibers in molecular transport through
the extracellular matrix.
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