Simulation of Optical Breast Density Measurements Using Structured Light Illumination in A Patient-Specific Anatomical Breast Model Built from 3D MRI-Segmented Breast Density

Diffuse Optical Imaging can potentially be used to measure quantitative breast density. We used MRI-based density segmented from healthy breasts to reconstruct a 3D model of the breast and the dense tissue for optical imaging simulation. Near infrared lights of various patterns were illuminated to the breast from one side and received from the other side. The light propagation through the 3D tissue model was simulated and reconstructed to generate the 3D absorption maps. The percentage of the high-absorbing dense tissue from the optical reconstructions is highly correlated with the true percent density measured by MRI, with r= 0.9866.

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