QQ quantification analysis of DCE-MRI for Osteosarcoma

We present a quantile-quantile (QQ) plot quantification method to measure the changes between the baseline and the following DCE-MRI examinations on a single phase II trial for pediatric osteosarcoma (OS) patients. The QQ quantification analysis could generate five QQ parameters to describe the different characteristics of the change of histograms in tumors between two serial DCE-MRI examinations. We found that the QQ quantification could potentially provide very early biomarkers for histologic response and event free survival analysis, but the mean value of DCE-MRI parameters in the tumors didnt provide such early biomarkers in a statistical analysis of 31 OS patients.

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