Abstract #4079
Early assessment of sequential combined therapy with radiation and sorafenib for hepatocellular carcinoma using quantitative perfusion and diffusion weighted magnetic resonance imaging: a pilot study
Hyunki Kim 1 , Desiree Morgan 1 , David Sarver 2 , Kyle Lee 1 , T. Beasley 1 , and Kimberly Keene 1
1
University of Alabama at Birmingham,
Birmingham, AL, United States,
2
University
of Arkansas for Medical Sciences, AR, United States
DCE-MRI/DWI was successfully applied for patients with
HCCs to quantitate the perfusion and diffusion
parameters of HCCs. Significant decreases of Ktrans and
kep values were observed after sequential combination
therapy with radiation and sorafenib, while tumor ADC
values were significantly increased. Tumor Ktrans change
was significantly correlated with tumor-volume change,
and therefore it may serve as an effective surrogate
biomarker to assess the therapeutic efficacy of
radiation therapy alone or in combination with
sorafenib.
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