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Abstract #4079

Early assessment of sequential combined therapy with radiation and sorafenib for hepatocellular carcinoma using quantitative perfusion and diffusion weighted magnetic resonance imaging: a pilot study

Hyunki Kim 1 , Desiree Morgan 1 , David Sarver 2 , Kyle Lee 1 , T. Beasley 1 , and Kimberly Keene 1

1 University of Alabama at Birmingham, Birmingham, AL, United States, 2 University of Arkansas for Medical Sciences, AR, United States

DCE-MRI/DWI was successfully applied for patients with HCCs to quantitate the perfusion and diffusion parameters of HCCs. Significant decreases of Ktrans and kep values were observed after sequential combination therapy with radiation and sorafenib, while tumor ADC values were significantly increased. Tumor Ktrans change was significantly correlated with tumor-volume change, and therefore it may serve as an effective surrogate biomarker to assess the therapeutic efficacy of radiation therapy alone or in combination with sorafenib.

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