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Abstract #4085

Diffusion weighted MR derived apparent diffusion co-efficient values as a biomarker for treatment response in breast cancer

Eimear Ann Joyce 1 , Sylvia A O'Keeffe 1 , Andrew Fagan 1,2 , Jason McMorrow 1 , Danielle Byrne 1 , John Kennedy 3 , and James F Meaney 1,2

1 Centre for Advanced Medical Imaging, St. James's Hospital, Dublin 8, Dublin, Ireland, 2 Trinity College Dublin, Dublin 2, Ireland, 3 HOPE Directorate, St. James' Hospital, Dublin, Ireland

The purpose of this study was to evaluate the performance of tumor apparent diffusion coefficient (ADC) values in predicting response early in the course of chemotherapy, for patients with breast cancer. We also assessed the effect of tumor marker clip placement on the ADC value. Our results confirm that changes in ADC values early in the course of treatment can predict treatment response. The gel-containing clip, used for tumor marking prior to neoadjuvant chemotherapy, results in a potential source of error when calculating ADC tumor values and should be avoided when drawing tumor regions of interest.

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