Meeting Banner
Abstract #4086

Entropy and Higher Order Moment Analysis of Pixel DCE-MRI Parameters for Breast Cancer Diagnosis

Mohan Jayatilake 1 , Xubo Song 1 , Alina Tudorica 1 , Yiyi Chen 1 , Karen Oh 1 , Nicole Roy 1 , Mark Kettler 1 , and Wei Huang 1

1 Oregon Health & Science University, Portland, Oregon, United States

Pre-biopsy DCE-MRI data from 82 mammography- and/or ultrasound-detected suspicious lesions were collected and analyzed using the Standard and Shutter-Speed PK models. Mean, higher order moments, and entropy of the pixel PK parameters were calculated. The higher order moments and entropy of the Ktrans and DeltaKtrans parameters provided comparable diagnostic accuracy as the mean metric, suggesting tumor perfusion heterogeneity can be used to discriminate benign and malignant breast lesions. The utility of spatial heterogeneity of the PK parameters will be investigated in future studies.

This abstract and the presentation materials are available to members only; a login is required.

Join Here