Towards quantitative T2- and ADC-mapping in prostate using diffusion weighted 3D DESS MRI

The purpose of this work was to apply diffusion weighted 3D DESS MRI to prostate imaging with the goal to achieve simultaneously quantitative T2- and ADC-mapping. Diffusion weighted DESS in the prostate is challenging due to motion, which limits SNR especially on the diffusion weighted echo-signal. Therefore only moderate diffusion gradient moments could be applied. Preliminary results in a healthy volunteer showed that quantitative T2 and ADC-values were within expected range for healthy prostate. Monte Carlo simulations showed good accuracy and precision for T2, however less for ADC-mapping. Simulated scenarios showed that improving SNR and/or diffusion sensitivity will improve quantification.

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