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Abstract #4110

Diffusion and Perfusion Coefficients Changes of Prostate Cancer after Endocrine Therapy: Using DWI Biexponential Model

Feiyu Li 1 , Wenchao Cai 1 , Jintang Ye 1 , Queenie Chan 2 , Xiaoying Wang 1 , and Xuexiang Jiang 1

1 Department of Radiology, Peking University First Hospital, Beijing, Beijing, China, 2 Philips Healthcare, Hong Kong, China

Accurate identification of the recurrent tumor in prostate allows better selection of patients for salvage or adjuvant RT after endocrine therapy. The purpose of this study was to assess the diffusion and perfusion coefficients changes of prostate cancer (PCa) and noncancerous areas after endocrine therapy using DWI biexponential model. The mean D and f values of cancerous and noncancerous foci in the endocrine treatment group both showed statistically different from that in the non-treatment group. The changes of the D and f were accordance with the pathological and physiological degeneration of cells and vessels after endocrine therapy in the histopathologic study. IVIM maybe a promising technique in the better detection of the prostate recurrent lesion after therapy.

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