Abstract #4111
MONITORING LOW-RISK PROSTATE CANCER WITH DIFFUSION-WEIGHTED MRI: ADC AND ITS RELATIONSHIP TO GROWTH RATE
Veronica A Morgan 1 , Chris C Parker 2 , Sharon L Giles 1 , and Nandita M de Souza 3
1
Clinical Magnetic Resonance Unit, Royal
Marsden NHS Foundation Trust, Sutton, Surrey, United
Kingdom,
2
Academic
Urology, Royal Marsden NHS Foundation Trust, Sutton,
Surrey, United Kingdom,
3
Clinical
Magnetic Resonance Unit, Institute of Cancer Research,
Sutton, Surrey, United Kingdom
This study evaluates the relationship between ADC and
tumor growth in low risk prostate cancer patients. Tumor
volume was calculated on baseline and follow-up scans of
23 patients. From the baseline scan a representative
tumor ADC was also derived from a ROI drawn around the
largest area of tumor. There was a significant negative
correlation between tumor growth rate and ADC at
presentation. In this low risk group doubling time is
around 3years. Cancers with lower ADC at the outset
tended to grow more quickly. Determining threshold ADCs
from a larger study could influence decisions around
timing of treatment.
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