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Abstract #4121

Comparison of Systematic and MRI-Ultrasound Fusion Targeted Prostate Biopsies in Men With No Prior Biopsies

Daniel Margolis 1 , Edward Chang 2 , Frederick Dorey 3 , Jesse Le 2 , Patricia Lieu 2 , and Leonard Marks 2

1 Department of Radiological Sciences, UCLA, Los Angeles, CA, United States, 2 Urology, UCLA, Los Angeles, CA, United States, 3 Biostatistics, UCLA, Los Angeles, CA, United States

MRI-ultrasound fusion targeted prostate biopsy has shown improved yield for significant cancer in men with prior negative biopsies and undergoing active surveillance. It has also been shown to improve yield for the initial biopsy session. We present a comparison of systematic versus targeted biopsy yield in men with elevated PSA but no prior biopsies using 4 definitions of significant disease. The rates of detection were similar, although both systematic and targeted biopsies miss significant disease for all definitions. However, this detection rate occurred with nearly twice as many systematic as targeted biopsy cores.

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