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Abstract #4122

Does the grade hotspot match the volume hotspot? A 3-D model reconstructed using Template Prostate Mapping Biopsies from the MRC PROMIS trial

Ahmed El-Shater Bosaily 1 , Massimo Valerio 1 , Yipeng Hu 2 , Alex Freeman 3 , Charles Jameson 3 , Louise Brown 4 , Richard Kaplan 4 , Mark Emberton 1 , Chris Parker 5 , Richard Hindley 6 , and Hashim Ahmed 1

1 Division of Surgery and interventional science, University College London, London, United Kingdom, 2 Centre for Medical Image Computing, University college London, London, United Kingdom, 3 Pathology, University College London Hospitals NHS Foundation Trust, London, United Kingdom, 4 Clinical Trials Unit, Medical Research Council, London, United Kingdom, 5 oncology, Royal Marsden Hospital/Institute of Cancer Research., London, United Kingdom, 6 Urology, Hampshire Hospitals NHS Foundation Trust, Hampshire, United Kingdom

Currently, MRI guidance and planning is part of a rapidly growing trend of targeted prostate biopsies. Despite the assumption that the maximum cancer grade (grade hotspot) lies within the maximum dimension of the lesion (volume hotspot), some argue that it might not always be true and that areas of higher cancer grade may show different signal characteristics and may be identifiable on MRI.The aim of this study is to assess the concordance between the grade hotspot and the volume hotspot using TPM biopsies outputs from the pilot phase of the multicenter MRC PROMIS study

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