Abstract #4122
Does the grade hotspot match the volume hotspot? A 3-D model reconstructed using Template Prostate Mapping Biopsies from the MRC PROMIS trial
Ahmed El-Shater Bosaily 1 , Massimo Valerio 1 , Yipeng Hu 2 , Alex Freeman 3 , Charles Jameson 3 , Louise Brown 4 , Richard Kaplan 4 , Mark Emberton 1 , Chris Parker 5 , Richard Hindley 6 , and Hashim Ahmed 1
1
Division of Surgery and interventional
science, University College London, London, United
Kingdom,
2
Centre
for Medical Image Computing, University college London,
London, United Kingdom,
3
Pathology,
University College London Hospitals NHS Foundation
Trust, London, United Kingdom,
4
Clinical
Trials Unit, Medical Research Council, London, United
Kingdom,
5
oncology,
Royal Marsden Hospital/Institute of Cancer Research.,
London, United Kingdom,
6
Urology, Hampshire
Hospitals NHS Foundation Trust, Hampshire, United
Kingdom
Currently, MRI guidance and planning is part of a
rapidly growing trend of targeted prostate biopsies.
Despite the assumption that the maximum cancer grade
(grade hotspot) lies within the maximum dimension of the
lesion (volume hotspot), some argue that it might not
always be true and that areas of higher cancer grade may
show different signal characteristics and may be
identifiable on MRI.The aim of this study is to assess
the concordance between the grade hotspot and the volume
hotspot using TPM biopsies outputs from the pilot phase
of the multicenter MRC PROMIS study
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