Abstract #4164
Functional connectivity changes as detected by resting-state functional MRI: three cases of patients with focal cerebellar lesions
Giusy Olivito 1,2 , Marco Bozzali 3 , Marco Molinari 2 , Maria Leggio 1,2 , and Mara Cercignani 3,4
1
Department of Psychology, Sapienza
University of Rome, Rome, Italy,
2
Ataxia
Laboratory, IRCCS Santa Lucia, Rome, Italy,
3
Neuroimaging
Laboratory, IRCCS Santa Lucia, Rome, Italy,
4
Clinical
Imaging Science Center, Brighton and Sussex Medical
School, Brighton, United Kingdom
The cerebellar output channels have been demostrated to
be spatially segregated and to focus on functionally
distinct cortical systems, supporting the cerebellar
role in cognition. 3 cases of patients with left
cerebellar lesions were used to demonstrate the
sensitivity of resting-state (RS) fMRI to changes in
functional connectivity caused by the presence of the
lesion. Using the resting-state approach, we were able
to define the pattern of connectivity between cerebral
cortex and specific cerebellar lobuli. When comparing
each patient to the healthy participants, we found
different patterns of altered connectivity, involving
both contralateral and ipsilateral cortical areas.
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