Abstract #4168
Does caffeine ingestion alter brain metabolism?
Feng Xu 1,2 , Peiying Liu 3 , James J. Pekar 1,2 , and Hanzhang Lu 3
1
Russell H. Morgan Department of Radiology,
Johns Hopkins University, Baltimore, MD, United States,
2
F.M.
Kirby Research Center, Kennedy Krieger Institute,
Baltimore, MD, United States,
3
Advanced
Imaging Research Center, University of Texas
Southwestern Medical Center, Dallas, TX, United States
Caffeine has a vasoconstriction effect on vasculature.
However, its exact neuro-metabolic effect has not been
examined. We used TRUST MRI, phase-contrast MRI and
PCASL MRI to examine the dynamic changes of whole-brain
cerebral metabolic rate of oxygen (CMRO2), venous
oxygenation (Yv), cerebral blood flow (CBF) after
caffeine ingestion. Significant decreases of whole-brain
CBF and Yv were found, while no changes were present in
whole-brain CMRO2. Regional CBF revealed various decline
rates from global CBF, suggesting that neural metabolism
might paly a role of enhancing and suppressing CBF in
addition to vasoconstriction. Co-existing neural effects
lead to whole-brain CMRO2 unchanged.
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