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Abstract #4168

Does caffeine ingestion alter brain metabolism?

Feng Xu 1,2 , Peiying Liu 3 , James J. Pekar 1,2 , and Hanzhang Lu 3

1 Russell H. Morgan Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2 F.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States, 3 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States

Caffeine has a vasoconstriction effect on vasculature. However, its exact neuro-metabolic effect has not been examined. We used TRUST MRI, phase-contrast MRI and PCASL MRI to examine the dynamic changes of whole-brain cerebral metabolic rate of oxygen (CMRO2), venous oxygenation (Yv), cerebral blood flow (CBF) after caffeine ingestion. Significant decreases of whole-brain CBF and Yv were found, while no changes were present in whole-brain CMRO2. Regional CBF revealed various decline rates from global CBF, suggesting that neural metabolism might paly a role of enhancing and suppressing CBF in addition to vasoconstriction. Co-existing neural effects lead to whole-brain CMRO2 unchanged.

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