Does caffeine ingestion alter brain metabolism?
Feng Xu 1,2 , Peiying Liu 3 , James J. Pekar 1,2 , and Hanzhang Lu 3
Russell H. Morgan Department of Radiology,
Johns Hopkins University, Baltimore, MD, United States,
Kirby Research Center, Kennedy Krieger Institute,
Baltimore, MD, United States,
Imaging Research Center, University of Texas
Southwestern Medical Center, Dallas, TX, United States
Caffeine has a vasoconstriction effect on vasculature.
However, its exact neuro-metabolic effect has not been
examined. We used TRUST MRI, phase-contrast MRI and
PCASL MRI to examine the dynamic changes of whole-brain
cerebral metabolic rate of oxygen (CMRO2), venous
oxygenation (Yv), cerebral blood flow (CBF) after
caffeine ingestion. Significant decreases of whole-brain
CBF and Yv were found, while no changes were present in
whole-brain CMRO2. Regional CBF revealed various decline
rates from global CBF, suggesting that neural metabolism
might paly a role of enhancing and suppressing CBF in
addition to vasoconstriction. Co-existing neural effects
lead to whole-brain CMRO2 unchanged.
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