Abstract #4169
THALAMIC DYSFUNCTION IS ASSOCIATED WITH FATIGUE IN PATIENTS WITH MULTIPLE SCLEROSIS: A GRAPH THEORY STUDY
Maria A. Rocca 1 , Paola Valsasina 1 , Alvino Bisecco 1 , Alessandro Meani 1 , Laura Parisi 1 , Maria Jos Messina 2 , Bruno Colombo 2 , Andrea Falini 3 , Giancarlo Comi 2 , and Massimo Filippi 1
1
Neuroimaging Research Unit, Institute of
Experimental Neurology, San Raffaele Scientific
Institute, Vita-Salute San Raffaele University, Milan,
MI, Italy,
2
Department of Neurology, San
Raffaele Scientific Institute, Vita-Salute San Raffaele
University, Milan, MI, Italy,
3
Department
of Neuroradiology, San Raffaele Scientific Institute,
Vita-Salute San Raffaele University, Milan, MI, Italy
Resting state functional MRI (RS fMRI) and graph theory
were applied to explore abnormalities of large-scale
brain networks (connectome) in 64 patients with multiple
sclerosis (MS) and fatigue (F). As control groups, 60 MS
patients without fatigue (NF) and 59 healthy controls
(HC) were included. F-MS patients, unlike HC and NF-MS
patients, lost hubs in the thalami and middle cingulate
cortex. Compared to HC and NF-MS patients, F-MS patients
experienced a decreased degree in the bilateral
thalamus. Fatigue in MS is related to a functional
disruption of the thalamic connector, which should be
the target of potential therapeutic interventions.
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