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Abstract #4171

Assessing vascular reactivity with resting-state BOLD signal fluctuations: a clinically practical alternative to the breath-hold challenge

Hesamoddin Jahanian 1 , Wendy W Ni 1 , Thomas Christen 1 , Michael E Moseley 1 , Manjula K Tamura 2 , and Greg Zaharchuk 1

1 Stanford University, Department of Radiology, Stanford, California, United States, 2 Stanford University, Division of Nephrology, Stanford, California, United States

In this work, we hypothesized that the spontaneous resting state BOLD signal fluctuations can be viewed as the response of the brain to the internal challenges to the cerebrovascular system, including heartbeat, inhalation, and baseline neuronal activity and may provide information about cerebrovascular reactivity. To test this hypothesis we compared the magnitude of rsBOLD signal fluctuations to the cerebrovascular reactivity measured as percentage signal change during a breath-holding challenge in a population of older adults (N=30). Our results indicate a strong linear relation between the magnitude of rsBOLD signal fluctuations and breath-holding percentage signal change across subjects.

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