Abstract #4171
Assessing vascular reactivity with resting-state BOLD signal fluctuations: a clinically practical alternative to the breath-hold challenge
Hesamoddin Jahanian 1 , Wendy W Ni 1 , Thomas Christen 1 , Michael E Moseley 1 , Manjula K Tamura 2 , and Greg Zaharchuk 1
1
Stanford University, Department of
Radiology, Stanford, California, United States,
2
Stanford
University, Division of Nephrology, Stanford,
California, United States
In this work, we hypothesized that the spontaneous
resting state BOLD signal fluctuations can be viewed as
the response of the brain to the internal challenges to
the cerebrovascular system, including heartbeat,
inhalation, and baseline neuronal activity and may
provide information about cerebrovascular reactivity. To
test this hypothesis we compared the magnitude of rsBOLD
signal fluctuations to the cerebrovascular reactivity
measured as percentage signal change during a
breath-holding challenge in a population of older adults
(N=30). Our results indicate a strong linear relation
between the magnitude of rsBOLD signal fluctuations and
breath-holding percentage signal change across subjects.
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