Abstract #4172
Aging-Related Reduction in Physiological Signal Contribution to Resting State fMRI
Wendy W Ni 1,2 , Catie Chang 3 , Hesamoddin Jahanian 2 , Gary H Glover 2 , and Greg Zaharchuk 2
1
Department of Electrical Engineering,
Stanford University, Stanford, CA, United States,
2
Department
of Radiology, Stanford University, Stanford, CA, United
States,
3
Advanced
MRI Section, LFMI, NINDS, NIH, Bethesda, MD, United
States
In this study, we analyze the percentage of resting
state BOLD fMRI signal variance attributable to cardiac
and respiratory fluctuations, as quantified using the
RVHR model, in young normal subjects, elderly subjects
with hypertension and chronic kidney disease, and
elderly normal subjects. We found a statistically
significant difference (p<0.05 with Bonferroni
correction) between the young group and each elderly
group, but not between the elderly groups. This finding
supplements previous work to indicate an association of
aging with increased non-physiological fluctuations
and/or reduction or change in neurovascular response to
physiological stimulation in resting state.
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