Lithium effect on functional networks of HIV infected individuals as revealed by Generalized Partial Directed Coherence measures.
Madalina E Tivarus 1 , Britta Pester 2 , Tong Zhu 3 , Christoph Schmidt 2 , Thomas Lehmann 2 , Jianhui Zhong 1 , Lutz Leistritz 2 , and Giovanni Schifitto 1
University of Rochester, Rochester, NY,
of Medical Statistics, Computer Sciences and
Documentation, Jena University Hospital, Friedrich
Schiller University, Jena, Germany,
of Michigan, Ann Arbor, MI, United States
Generalized Partial Directed Coherence (gPDC) was
applied on fMRI data to evaluate changes in functional
networks and their connectivity in HIV infected
individuals treated with lithium for HIV-associated
cognitive impairment. GPDC analysis shows that lithium
affected functional connectivity and it provides a
paradigm to investigate functional and anatomical
interrelationships in the context of clinical changes.
Therefore, applying gPDC on functional MRI data provides
an opportunity to further dissect the functional changes
observed in relevant networks affected by the
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