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Abstract #4188

Lithium effect on functional networks of HIV infected individuals as revealed by Generalized Partial Directed Coherence measures.

Madalina E Tivarus 1 , Britta Pester 2 , Tong Zhu 3 , Christoph Schmidt 2 , Thomas Lehmann 2 , Jianhui Zhong 1 , Lutz Leistritz 2 , and Giovanni Schifitto 1

1 University of Rochester, Rochester, NY, United States, 2 Institute of Medical Statistics, Computer Sciences and Documentation, Jena University Hospital, Friedrich Schiller University, Jena, Germany, 3 University of Michigan, Ann Arbor, MI, United States

Generalized Partial Directed Coherence (gPDC) was applied on fMRI data to evaluate changes in functional networks and their connectivity in HIV infected individuals treated with lithium for HIV-associated cognitive impairment. GPDC analysis shows that lithium affected functional connectivity and it provides a paradigm to investigate functional and anatomical interrelationships in the context of clinical changes. Therefore, applying gPDC on functional MRI data provides an opportunity to further dissect the functional changes observed in relevant networks affected by the intervention.

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