Abstract #4189
rsfMRI and 1H MRS in sub-chronic phencyclidine (PCP) rat model of cognitive impairment in schizophrenia. A longitudinal study to assess prevention of cognitive impairment deficit
Daniele Procissi 1 , Kathleen Anne Williams 1 , Lakshmi Rajagopal 2 , Yoshihiro Oyamada 2,3 , and Herbert Meltzer 2
1
Radiology, Northwestern University, Chicago,
IL, United States,
2
Psychiatry
and Behavioral Sciences, Northwestern University,
Chicago, Illinois, United States,
3
Dainippon
Sumitomo Pharma Co., Ltd, Japan
The aim of this work is to use 1H-MRS and fMRI to detect
changes in metabolism and connectivity that reflect the
behavioral changes and ultimately to evaluate MRI as a
potential predictor of successful pharmacological
prevention of cognitive impairment in a PCP rat model of
schizophrenia .
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