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Abstract #4197

Latency time variability hinders ASL fMRI analyses

Joao M. S. Pereira 1 , Joo Duarte 2 , Miguel Raimundo 3 , and Miguel Castelo-Branco 4

1 Laboratory of Biostatistics, IBILI - Faculty of Medicine, University of Coimbra, Coimbra, Portugal, 2 ICNAS - Faculty of Medicine, University of Coimbra, Coimbra, Portugal, 3 Clinical School - Faculty of Medicine, University of Coimbra, Coimbra, Portugal, 4 Visual Sciences Laboratory, IBILI - Faculty of Medicine, University of Coimbra, Coimbra, Portugal

For functional imaging purposes, Arterial Spin Labeling (ASL) has the advantage of measuring activity directly related to neuronal activation with greater localizing sensitivity than the more common BOLD signal analyses. The application of ASL in the fMRI context has, however, been blighted by subpar performances. This work addresses the variability of the latency in the hemodynamic response function (HRF) in both healthy controls and diabetes type II patients, known to have changes in brain vasculature. A method is presented to bypass this limitation in ASL fMRI.

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