Deoxyhemoglobin and hypercapnia based fMRI calibration methods

Our objective was to compare the fMRI calibration parameter (M) quantified with two methods and to establish a mutual scaling factor. Deoxyhemoglobin based calibration was achieved by quantifying R2 to yield MR2 after magnetic field inhomogeneity correction. Calibration exploiting the fractional change in cerebral blood flow during hypercapnia was obtained by ASL, providing along with the measured change in BOLD Mhypercapnia via Davis model. Preliminary results show comparable calibration M values for the two methods. The quantitative scaling factor might provide potential support for the R2 calibration method, which is more straightforward to implement.

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