The End-Tidal CO2 Response Function in Resting-State BOLD fMRI
Ali M Golestani 1,2 and J Jean Chen 1,2
Rotman Research Institute, Baycrest,
Toronto, ON, Canada,
of Toronto, Toronto, ON, Canada
End-tidal CO2 (PETCO2) fluctuations constitute a source
of physiological noise in the BOLD fMRI signal. In this
study we estimate the hemodynamic response of the
resting-state BOLD signal to spontaneous PETCO2
fluctuations. Cardiac, respiratory and PETCO2 signals
were recorded during resting-state fMRI scan. The
response is estimated voxel-wise in 8 subjects. The
estimated PETCO2 response has a peak around 9 seconds,
which is in accordance with previously reported results.
There is some overlap between the regions most affected
by RVT and by PETCO2 fluctuations showing possible
interaction between the two, but they each modulates the
BOLD signal in unique ways.
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