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Abstract #4207

Associations of Resting-State fMRI Functional Connectivity with Flow-BOLD Coupling and Regional Vasculature

Sungho Tak 1 , Danny J. J. Wang 2 , Jonathan R. Polimeni 3 , Lirong Yan 2 , and J. Jean Chen 1

1 Rotman Research Institute at Baycrest Centre, Toronto, ON, Canada, 2 Laboratory of Functional MRI Technology (LOFT), University of California, Los Angeles, CA, United States, 3 Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA, United States

In this study, we investigated regional associations of resting-state functional connectivity MRI (fcMRI) estimates with cerebral blood flow (CBF)-BOLD coupling, as well as the role of large vessel volume. Based on extensive analyses, we found that functional connectivity strength was significantly proportional to the regional strength in CBF-BOLD coupling, and inversely proportional to large-vessel volume fraction. Our work suggests that despite inherent ambiguity of fcMRI estimates, synchronized activities observed in the functional networks are not likely to be mediated by common vascular drainage linking distal cortical areas, but rather by tighter CBF-BOLD coupling, which might be associated with neuronal connection.

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