Abstract #4319
Comparison of accelerated T1-weighted whole-brain structural imaging protocols
Pavel Falkovskiy 1,2 , Daniel Brenner 3 , Thorsten Feiweier 4 , Stephan Kannengiesser 4 , Bndicte Marchal 1,2 , Tobias Kober 1,2 , Alexis Roche 1,5 , Kaely Thostenson 6 , Denise Reyes 6 , Matthias Seeger 7 , Tony Stoecker 3 , Matt Bernstein 6 , and Gunnar Krueger 1,2
1
Advanced Clinical Imaging Technology,
Siemens Healthcare IM BM PI, Lausanne, Switzerland,
2
CIBM
- AIT, cole Polytechnique Fdrale de Lausanne,
Lausanne, Switzerland,
3
German
Center for Neurodegenerative Diseases (DZNE), Bonn,
Germany,
4
Healthcare
Sector, Siemens AG, Erlangen, Germany,
5
Department
of Radiology, University Hospital (CHUV), Lausanne,
Switzerland,
6
Department
of Radiology, Mayo Clinic, Rochester, Minnesota, United
States,
7
Laboratory
for Probabilistic Machine Learning, cole Polytechnique
Fdrale de Lausanne, Lausanne, Switzerland
The MPRAGE pulse sequence is often used for structural
brain imaging because of its good GM/WM contrast.
Recently, several strategies beyond conventional
parallel imaging have been proposed that can be applied
to further shorten the several-minute-long 3D whole
brain acquisition time, e.g. 2D-GRAPPA, CAIPIRINHA, and
segmented MPRAGE. This work qualitatively and
quantitatively compares the performance of four 3-minute
MPRAGE variants of the frequently employed 5-minute
ADNI-2 3D brain imaging protocol. All images obtained
with a 3-minute protocol are rated as being of
clinically useful image quality, though the fast
protocols are found to introduce systematic deviations
in automated volumetric measurements.
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