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Abstract #4319

Comparison of accelerated T1-weighted whole-brain structural imaging protocols

Pavel Falkovskiy 1,2 , Daniel Brenner 3 , Thorsten Feiweier 4 , Stephan Kannengiesser 4 , Bndicte Marchal 1,2 , Tobias Kober 1,2 , Alexis Roche 1,5 , Kaely Thostenson 6 , Denise Reyes 6 , Matthias Seeger 7 , Tony Stoecker 3 , Matt Bernstein 6 , and Gunnar Krueger 1,2

1 Advanced Clinical Imaging Technology, Siemens Healthcare IM BM PI, Lausanne, Switzerland, 2 CIBM - AIT, cole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland, 3 German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 4 Healthcare Sector, Siemens AG, Erlangen, Germany, 5 Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, 6 Department of Radiology, Mayo Clinic, Rochester, Minnesota, United States, 7 Laboratory for Probabilistic Machine Learning, cole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland

The MPRAGE pulse sequence is often used for structural brain imaging because of its good GM/WM contrast. Recently, several strategies beyond conventional parallel imaging have been proposed that can be applied to further shorten the several-minute-long 3D whole brain acquisition time, e.g. 2D-GRAPPA, CAIPIRINHA, and segmented MPRAGE. This work qualitatively and quantitatively compares the performance of four 3-minute MPRAGE variants of the frequently employed 5-minute ADNI-2 3D brain imaging protocol. All images obtained with a 3-minute protocol are rated as being of clinically useful image quality, though the fast protocols are found to introduce systematic deviations in automated volumetric measurements.

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