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Abstract #4320

10-Minute High-Resolution Whole-Brain T 1 Mapping: A Comparison of Three Candidate Methods

James A. Rioux 1 , Ives R. Levesque 1,2 , Manojkumar Saranathan 1 , and Brian K. Rutt 1

1 Radiology, Stanford University, Stanford, CA, United States, 2 Medical Physics, Oncology, and RI-MUHC, McGill University, Montreal, QC, Canada

Three methods for whole-brain high-resolution T 1 mapping are evaluated at 7T: 3-TI MPRAGE, MP2RAGE and MP3RAGE. Each acquires a number of T 1 -weighted MPRAGE images, allowing lookup of T 1 values instead of a least-squares fit, and is B 1 -insensitive to varying degrees. All acquisitions were matched at 10min total scan time and 1mm isotropic resolution. MP2RAGE demonstrated the highest T 1 -to-Noise-Ratio, while 3-TI MPRAGE had the lowest difference from a reference map but has reduced T 1 NR due to the acceleration required to achieve the desired scan time. MP3RAGE is a good compromise method, with.higher T 1 NR than 3-TI MPRAGE, but higher accuracy than MP2RAGE.

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