Abstract #4420
Mathematical models of colorectal tumour microstructure informed by oscillating gradients diffusion MRI
Alessandro Proverbio 1 , Bernard M. Siow 2,3 , Eleftheria Panagiotaki 3 , Samuel Walker-Samuel 2 , Mark F. Lythgoe 2 , Adam P. Gibson 1 , and Daniel C. Alexander 3
1
Medical Physics and Bioengineering,
University College London, London, United Kingdom,
2
Centre
for Advanced Biomedical Imaging, Division of Medicine,
University College London, London, United Kingdom,
3
Centre
for Medical Image Computing and Department of Computer
Science, University College London, London, United
Kingdom
Investigation of tissue microstructure with non-invasive
histology is a developing research area. Diffusion MRI
(dMRI) can estimate features of microstructural
components such as cell cytoarchitecture. Here develop
signal models for Square Wave Oscillating Gradient Spin
Echo (SWOGSE) dMRI. This study is performed on fixed
subcutaneous xenograft tumour samples grown in nude
mice: 3 LS174T, and 3 SW1222 cell lines. Oscillating
Gradient Spin Echo probes shorter length scales than
standard PGSE. The more tissue-like compartment model
appears to represent the signal better, suggesting the
feasibility of a clinical measurement of cytological
properties of the tissue.
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