Quantifying in-vivo changes in myofiber diameter due to muscular atrophy with time-dependent diffusion MRI
Gregory Lemberskiy 1,2 , Els Fieremans 1 , Thorsten Feiweier 3 , Leon Axel 1 , and Dmitry S Novikov 1
New York University School of Medicine,
Bernard and Irene Schwartz Center for Biomedical
Imaging, Department of Radiology, New York, NY, United
Institute of Graduate Biomedical Sciences, New York
University School of Medicine, New York, NY, United
AG, Healthcare Sector, Erlangen, Germany
The random permeable barrier model (RPBM) utilizes
time-dependent diffusion to quantify cell size and
membrane permeability. Human in-vivo RPBM validation was
performed on individuals that experienced calf muscle
atrophy while immobilized in a non-weight bearing cast.
The RPBM was used to quantify the difference of myofiber
size in immobilized and control calf muscles. Muscle
groups of immobilized calf muscles of all volunteers
were significantly smaller than those of the control
leg. Additionally, the RPBM revealed that certain muscle
groups atrophied less due to degrees of freedom offered
by the cast.
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