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Abstract #4423

Quantifying in-vivo changes in myofiber diameter due to muscular atrophy with time-dependent diffusion MRI

Gregory Lemberskiy 1,2 , Els Fieremans 1 , Thorsten Feiweier 3 , Leon Axel 1 , and Dmitry S Novikov 1

1 New York University School of Medicine, Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York, NY, United States, 2 Sackler Institute of Graduate Biomedical Sciences, New York University School of Medicine, New York, NY, United States, 3 Siemens AG, Healthcare Sector, Erlangen, Germany

The random permeable barrier model (RPBM) utilizes time-dependent diffusion to quantify cell size and membrane permeability. Human in-vivo RPBM validation was performed on individuals that experienced calf muscle atrophy while immobilized in a non-weight bearing cast. The RPBM was used to quantify the difference of myofiber size in immobilized and control calf muscles. Muscle groups of immobilized calf muscles of all volunteers were significantly smaller than those of the control leg. Additionally, the RPBM revealed that certain muscle groups atrophied less due to degrees of freedom offered by the cast.

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