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Abstract #4424

Diffusion modeling in brain cell geometries parameterized according to morphometric statistics

Julien Valette 1

1 Molecular Imaging Research Center (MIRCen), Commissariat l'Energie Atomique, Fontenay-aux-Roses, France

An original diffusion modeling approach is proposed to capture some features of brain cells complexity and heterogeneity, while parameterizing the model with only a small set of parameters based on cell morphometric statistics as derived from microscopy. We exemplify how this approach allows evaluating the effect of long-range cell morphology (i.e. cellular processes branching and length) on the apparent diffusion coefficient (ADC) of intracellular molecules, as might be measured by diffusion-weighted MRI/spectroscopy at long diffusion times Td.

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