Abstract #4425
Inverse Laplace transform analysis of the DWI MRI signal in prostate and bladder
Milica Medved 1 , Shiyang Wang 1 , Steffen Sammet 1 , Ambereen Yousuf 1 , Gregory S Karczmar 1 , and Aytekin Oto 1
1
Radiology, University of Chicago, Chicago,
Illinois, United States
The non-mono-exponential nature of the DWI signal decay
in the prostate is well established. Current advanced
modeling methods use a two component model, and the data
is fit for the fast (corresponding to the coherent
motion in blood vessels) and slow (describing the
inherent diffusion properties of the glandular tissue)
components. Using a new implementation of the inverse
Laplace transform, we present evidence that multiple
slow components can be present in the decaying DWI
signal. We demonstrate evidence for single-component
diffusion in the bladder, and for presence of up to
three components in the peripheral zone of the prostate.
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