Abstract #4426
3D structure tensor analysis of light microscopy data for validating diffusion MRI
Ahmad Raza Khan 1,2 , Lindsey A Leigland 3 , Steven G Kohama 1 , Anda Cornea 1 , Sune Nrhj Jespersen 4 , and Christopher D Kroenke 1,2
1
Division of Neuroscience, Oregon National
Primate Research Center, Oregon Health & Science
University, Beaverton, Oregon, United States,
2
Advanced
Imaging Research Center, Oregon Health & Science
University, Portland, Oregon, United States,
3
Advanced
Imaging Research Center, Oregon Health & Science
University, Beaverton, Oregon, United States,
4
Center
of Functionally Integrative Neuroscience, Aarhus
University Hospital, Aarhus, Denmark
Recently, two-dimensional structure tensor (ST) analysis
has been applied to light microscopy images for the
purpose of validating diffusion anisotropy measurements.
The ST analysis strategy enables the microscopy data to
be analyzed in a high-throughput manner, and hence is
suitable for group-comparison studies. However, 2D
analyses are restricted to directions parallel to the
imaging plane. Here we show it is possible to extend ST
analyses to 3D using serial image "stacks" acquired with
confocal microscopy of nonhuman primate brain tissue. It
is expected that this generalization of the ST analysis
will extend its range of applications in future studies.
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