Abstract #4435
Magnetic resonance microscopy of fixed breast tissue
Narina Norddin 1,2 , Ned Charles 1 , Nyoman Kurniawan 3 , Gary Cowin 3 , Laurence Gluch 4 , Carl Power 5 , Geoffrey Watson 6 , and Roger Bourne 1
1
Faculty of Health Sciences, University of
Sydney, Camperdown, NSW, Australia,
2
Kulliyyah
of Allied Health Sciences, International Islamic
University Malaysia, Kuantan, Pahang, Malaysia,
3
University
of Queensland, Brisbane, Queensland, Australia,
4
The
Strathfield Breast Centre, Strathfield, NSW, Australia,
5
University
of New South Wales, Sydney, NSW, Australia,
6
Royal
Prince Alfred Hospital, Sydney, NSW, Australia
Conventional MRI has high sensitivity for breast cancer
detection but poor specificity.Addition of DWI to a
breast exam may increase specificity to around
90%.However,the biophysical basis of changes in
diffusion weighted contrast in the breast and other
non-neural tissue remains poorly understood.The study
described here investigates the microscopic diffusion
properties of formalin fixed breast tissue.Breast tissue
glandular epithelium is similar to prostate tissue
epithelium in having a low ADC relative to adjacent
tissue.Low ADC may be a distinctive and diagnostically
useful feature of glandular epithelia,not only in
prostate and breast,particularly considering that 80-90%
of all cancers are of epithelial origin.
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