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Abstract #4435

Magnetic resonance microscopy of fixed breast tissue

Narina Norddin 1,2 , Ned Charles 1 , Nyoman Kurniawan 3 , Gary Cowin 3 , Laurence Gluch 4 , Carl Power 5 , Geoffrey Watson 6 , and Roger Bourne 1

1 Faculty of Health Sciences, University of Sydney, Camperdown, NSW, Australia, 2 Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, Kuantan, Pahang, Malaysia, 3 University of Queensland, Brisbane, Queensland, Australia, 4 The Strathfield Breast Centre, Strathfield, NSW, Australia, 5 University of New South Wales, Sydney, NSW, Australia, 6 Royal Prince Alfred Hospital, Sydney, NSW, Australia

Conventional MRI has high sensitivity for breast cancer detection but poor specificity.Addition of DWI to a breast exam may increase specificity to around 90%.However,the biophysical basis of changes in diffusion weighted contrast in the breast and other non-neural tissue remains poorly understood.The study described here investigates the microscopic diffusion properties of formalin fixed breast tissue.Breast tissue glandular epithelium is similar to prostate tissue epithelium in having a low ADC relative to adjacent tissue.Low ADC may be a distinctive and diagnostically useful feature of glandular epithelia,not only in prostate and breast,particularly considering that 80-90% of all cancers are of epithelial origin.

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