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Abstract #4434

In Vivo Observation of Time-Dependent Diffusion in White Matter in Humans

Lauren Burcaw 1 , Jelle Veraart 2 , Dmitry S Novikov 1 , and Els Fieremans 1

1 New York University School of Medicine, Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York, NY, United States, 2 Vision Lab, Department of Physics, University of Antwerp, Antwerp, Belgium

We report on time-dependent diffusion in white We report on time-dependent diffusion in white matter as measured on three normal human volunteers over diffusion times ranging from 26 to 400 ms. A decrease in axial diffusivity with time is found indicating the presence of restrictions to diffusion along the axonal direction. We also note a decrease in radial diffusion with respect to time, however this decrease is less pronounced. Our results imply that axial and possibly radial time-dependent diffusion may be observable using clinical systems.

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