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Abstract #4453

Rotating Field Gradient (RFG) Diffusion MRI for Mapping 3D Orientation Distribution Functions (ODFs) in the Human Brain

Alexandru V Avram 1 , Joelle E Sarlls 2 , Peter J Basser 1 , and Evren Ozarslan 3

1 Section on Tissue Biophysics and Biomimetics, NICHD, National Institutes of Health, Bethesda, MD, United States, 2 NINDS, National Institutes of Health, Bethesda, MD, United States, 3 Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States

Conventional methods for mapping 3D diffusion orientation distribution functions (dODFs) of neuronal microstructure require long acquisitions and are prone to quantitation errors due to subject motion. In this study we describe a method for directly measuring in vivo 3D dODFs with a novel technique called Rotating Field Gradient (RFG) diffusion MRI, which applies sinusoidal diffusion gradients in arbitrarily oriented planes to directly sample the dODFs along the axis of rotation. RFG dMRI represents a fast, direct and model-free method for mapping 3D ODFs that could represent a powerful alternative to conventional pulse-field gradient diffusion MRI techniques.

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