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Abstract #4457

Effect of Diffusion Time on Intravoxel Incoherent Motion Parameters in Abdominal Organs

Yeeliang Thian 1 , Matthew R. Orton 2,3 , David J. Collins 2,3 , James A. d'Arcy 2,3 , Martin O. Leach 2,3 , Thorsten Feiweier 4 , and Dow-Mu Koh 1

1 Department of Radiology, Royal Marsden Hospital, Sutton, Surrey, United Kingdom, 2 CR-UK and EPSRC Cancer Imaging Centre,Institute of Cancer Research UK, Surrey, United Kingdom, 3 Royal Marsden Hospital, Surrey, United Kingdom, 4 Siemens AG, Healthcare Sector, Erlangen, Germany

The intra-voxel incoherent motion (IVIM) model relates signal decay on diffusion-weighted MRI (DWI) to tissue characteristics of perfusion and diffusivity. We explored the effects of altering the diffusion time of DWI sequences on IVIM perfusion (f,D*) and diffusion (D) related parameters in abdominal organs of healthy volunteers. At longer diffusion times, the calculated perfusion fraction (f) was significantly increased while the effect on the D and D* parameters was more variable, depending on the organ under study. The diffusion time has a significant impact on measured IVIM parameters in abdominal organs and should be reported when employing the IVIM model.

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