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Abstract #4481

A New Algorithm to Estimate the Mean of A Group of Tract Bundles

Hsu Yung-Chin 1 and Tseng Isaac Wen-Yih 1,2

1 Center for Optoelectronic Medicine, College of Medicine, National Taiwan University, Taipei, Taipei, Taiwan, 2 Graduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, Taiwan

In the study, we propose a new algorithm to iteratively estimate the mean shape of a group of tract bundles. The basic idea of our algorithm is: performing registration on tract bundles and taking the average on orientation maps. The conversion from orientation maps to tract bundles is achieved via fiber-tracking algorithms, and the reverse way is via modeling the tract bundles as currents. The algorithm is demonstrated on ten right cingulum bundles, and the results show that this method could properly estimate the mean cingulum bundle. This method has the potential to facilitate computational anatomy of the brain.

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