Abstract #4484
New Insights into Rabbit Brain Development with Generalized Q-Sampling MRI
Fang-Yu Nien 1 , Seong Yong Lim 1 , Yu-Han Hong 1 , Ya-Han Chang 1 , and Jun-Cheng Weng 1,2
1
School of Medical Imaging and Radiological
Sciences, Chung Shan Medical University, Taichung,
Taiwan,
2
Department
of Medical Imaging, Chung Shan Medical University
Hospital, Taichung, Taiwan
Characterizing complex anatomy at different stages of
brain development not only aids in understanding this
highly ordered process but also provides clues to detect
abnormalities caused by genetic or environmental
factors. Diffusion MRI allows for the in vivo
delineation of white matter tracts in the brain in a
manner that is individualized to the particular
neuroanatomy of each subject. Diffusion anisotropy and
diffusivity change in some brain regions with
demyelinating disease and also with neural development.
Previously we used diffusion tensor imaging (DTI) to
detect the changes of white matter tracts of rabbit
during brain development. However, DTI suffers from
resolving the complicated neural structure, i.e. fiber
crossing, which is observed frequently during mature
period. Therefore the goal of this study was to
characterize the changes of quantitative diffusion
indices in the developing rabbit brains using
generalized q-sampling imaging (GQI).
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