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Abstract #4484

New Insights into Rabbit Brain Development with Generalized Q-Sampling MRI

Fang-Yu Nien 1 , Seong Yong Lim 1 , Yu-Han Hong 1 , Ya-Han Chang 1 , and Jun-Cheng Weng 1,2

1 School of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, 2 Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan

Characterizing complex anatomy at different stages of brain development not only aids in understanding this highly ordered process but also provides clues to detect abnormalities caused by genetic or environmental factors. Diffusion MRI allows for the in vivo delineation of white matter tracts in the brain in a manner that is individualized to the particular neuroanatomy of each subject. Diffusion anisotropy and diffusivity change in some brain regions with demyelinating disease and also with neural development. Previously we used diffusion tensor imaging (DTI) to detect the changes of white matter tracts of rabbit during brain development. However, DTI suffers from resolving the complicated neural structure, i.e. fiber crossing, which is observed frequently during mature period. Therefore the goal of this study was to characterize the changes of quantitative diffusion indices in the developing rabbit brains using generalized q-sampling imaging (GQI).

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