Abstract #4483
Reliable Analysis of Tract-specific Multiparametric MR Data via Automated Isolation of Nigro-Striatal Tract
Ryan Hutten 1 , Nisa Desai 1 , Demetrius Maraganore 2,3 , Robert R. Edelman 1,4 , and Ying Wu 1,5
1
Radiology, Northshore University Health
System, Evanston, IL, United States,
2
Neurology,
Northshore University Health System, IL, United States,
3
Neurology,
University of Chicago, IL, United States,
4
Radiology,
Northwestern University Feinberg School of Medicine,
Chicago, IL, United States,
5
Radiology,
University of Chicago, Chicago, IL, United States
Automated tract based diffusion tensor imaging (DTI) and
magnetization transfer ratio (MTR) of the nigro-striatal
tract (NST) represents a high innovative neuroimaging
approach in Parkinsons disease. The NST is a major
dopamine pathway that is critically involved in
Parkinsons Disease (PD) diagnosis and treatment
modulation. The development of the automated NST
overcomes the challenges associated with segmenting SN,
and the necessity of manual seed regions for
tractography. We demonstrate considerably improved
reliability that eliminates operator-induced error that
will benefit future longitudinal studies of Parkinson's
disease.
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