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Abstract #4490

Experimentally estimated non-Gaussian water diffusion at a large range of b-values

Louise Munk Rydtoft 1 , Brian Hansen 1 , Mikkel Bo Hansen 1 , and Sune Nrhj Jespersen 1,2

1 CFIN / MindLab, Aarhus university, Aarhus, Denmark, 2 Department of physics and astronomy, Aarhus University, Denmark

Conventionally DTI is deemed accurate for b-values below 1000 s/mm 2 and DKI for b-values below 2000 s/mm 2 . By analysing DKI and DTI fits on data from a human volunteer and perfusion fixated rat, we show the DKI model is a better fit for a linearly increasing ratio of voxels, independent on tissue type. Up to one-third of voxels are better fitted by DKI when maximum b-value is 1000 s/mm 2 . DKI is a convincing alternative to DTI, even at smaller b-values that has generally been accepted. Also, we show that the fixation process indeed restricts diffusion; this is disputed in the literature.

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