Meeting Banner
Abstract #4495

Demonstration of fast diffusion kurtosis MRI for imaging acute ischemic stroke diffusion/kurtosis lesion mismatch

Phillip Zhe Sun 1 , Yu Wang 1,2 , Emiri Mandeville 3 , Eng H Lo 3 , and Xunming Ji 2

1 Radiology, Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2 Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, China, 3 Department of Radiology and Neurology, Neuroprotection Research Laboratory, MA, United States

Diffusion kurtosis MRI (DKI) is a complementary index to stratify heterogeneous DWI deficit. However, DKI acquisition time is relatively long. Here, we tested a fast DKI approach, recently proposed by Hansen et al., using a rodent model of acute stroke. We found significant correlation, per pixel, between the diffusion and kurtosis coefficients measured using the standard and fast DKI protocols. We further demonstrated that diffusion and kurtosis lesion sizes defined using the fast and conventional DKI methods were in good agreement. Moreover, we showed that kurtosis lesion size was significantly smaller than that of diffusion lesions (7216%, P<0.01, Paired-t test).

This abstract and the presentation materials are available to members only; a login is required.

Join Here