Meeting Banner
Abstract #4496

Diffusional Kurtosis Imaging of White Matter and Gray Matter Lesions in Multiple Sclerosis: Combined Use with Double Inversion Recovery

Mariko Yoshida 1 , Masaaki Hori 1 , Kazumasa Yokoyama 2 , Nozomi Hamasaki 1 , Michimasa Suzuki 1 , Koji Kamagata 1 , Kohei Kamiya 1 , Shigeki Aoki 1 , Yoshitaka Masutani 3 , and Nobutaka Hattori 2

1 Department of Radiology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan, 2 Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan, 3 Division of Radiology and Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

The purpose of this study is to evaluate diffusional changes of the WM and GM including plaques, periplaque WM (PWM), periplaque GM (PGM), NAWM, and NAGM in MS by using a new method\DKI with double inversion recovery (DIR) to segment GM. The participants were 7 MS patients with GM plaques. DKI with DIR detected abnormalities in WM and GM with high sensitivity and can provide additional information on changes of WM and GM in MS. In contrast to WM plaques, there may be little change in the GM substance around GM plaques. MK may be a more sensitive biomarker of tissue damage in MS patients.

This abstract and the presentation materials are available to members only; a login is required.

Join Here