Abstract #4496
Diffusional Kurtosis Imaging of White Matter and Gray Matter Lesions in Multiple Sclerosis: Combined Use with Double Inversion Recovery
Mariko Yoshida 1 , Masaaki Hori 1 , Kazumasa Yokoyama 2 , Nozomi Hamasaki 1 , Michimasa Suzuki 1 , Koji Kamagata 1 , Kohei Kamiya 1 , Shigeki Aoki 1 , Yoshitaka Masutani 3 , and Nobutaka Hattori 2
1
Department of Radiology, Juntendo University
School of Medicine, Bunkyo, Tokyo, Japan,
2
Department
of Neurology, Juntendo University School of Medicine,
Tokyo, Japan,
3
Division
of Radiology and Biomedical Engineering, Graduate School
of Medicine, The University of Tokyo, Tokyo, Japan
The purpose of this study is to evaluate diffusional
changes of the WM and GM including plaques, periplaque
WM (PWM), periplaque GM (PGM), NAWM, and NAGM in MS by
using a new method\DKI with double inversion recovery
(DIR) to segment GM. The participants were 7 MS patients
with GM plaques. DKI with DIR detected abnormalities in
WM and GM with high sensitivity and can provide
additional information on changes of WM and GM in MS. In
contrast to WM plaques, there may be little change in
the GM substance around GM plaques. MK may be a more
sensitive biomarker of tissue damage in MS patients.
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