Abstract #4497
Comparison of Fitting Methods and b value Sampling Strategies for Intravoxel Incoherent Motion (IVIM) in Breast Cancer
Gene Young Cho 1 , Jeff L Zhang 2 , Linda Moy 1,3 , Steven Baete 1 , Melanie Moccaldi 3 , Sungheon Kim 1 , Daniel K Sodickson 1 , and Eric E Sigmund 1
1
Radiology - Bernard and Irene Schwartz
Center for Biomedical Imaging, New York University
School of Medicine, New York, Select, United States,
2
Radiology,
University of Utah, Salt Lake City, UT, United States,
3
Radiology,
New York University Cancer Institute, New York, NY,
United States
The selection of diffusion gradients for diffusion
weighted imaging (DWI) is important for protocol
optimization. It has been shown that different ranges of
gradients sensitize the signal to different components
of diffusion. Additionally, quantification of DWI data
with the biexponential IVIM fitting model can be
numerically nontrivial. In this study, we employ an
optimized b value selection for biexponential IVIM
analysis of breast lesions to increase measurement
precision. Eventually, optimization may lead to
increasing diagnostic differentiation between cancerous
subtypes and potentially allow more careful monitoring
of response to treatment.
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